APROTININ (a-pro-ti'nin) Trasylol Classifications: blood formers, coagulators, and anticoagulants; hemostatic Prototype: Aminocaproic acid Pregnancy Category: B |
10,000 KIU/mL injection (one KIU equals 0.14 mg)
Polypeptide of bovine origin that inhibits protease. By interaction with certain proteases, aprotinin has antifibrinolytic effect, hemostatic stabilizing effect, and weak anticoagulant effect.
Aprotinin reduces postoperative bleeding in coronary bypass surgery patients by inhibiting fibrinolytic activity while preserving platelet adhesive function and prolonging postoperative bleeding time.
Prophylactically to reduce perioperative blood loss and need for blood transfusions during cardiopulmonary bypass in the course of repeat coronary artery bypass surgery. May also be used in selected cases of primary coronary artery bypass graft surgery where the risk of bleeding is especially high (i.e., impaired hemostasis, coagulopathy).
Hypersensitivity to aprotinin and bovine products.
Patients with heparinized blood; patients previously treated with aprotinin; pregnancy (category B). Safety and efficacy in children are not established.
Cardiac Surgery Adult: IV Test Dose 1-mL (10,000 kallikrein inactivator units [KIU]) given at least 10 min prior to loading dose (observe for signs of an allergic reaction) IV Loading Dose 2 million KIU over 2030 min after induction of anesthesia, but prior to sternotomy, add 2 million KIU to the priming fluid of the cardiopulmonary priming pump IV Maintenance Dose Constant infusion of 500,000 KIU/h, continue until the patient leaves the OR |
Intravenous PREPARE: IV Test Dose/Loading Dose: Use as supplied (1 mL = 1.4 mg or 10,000 KIU) without further dilution. ADMINISTER: IV Test Dose: Give direct IV push over 1 min. IV Loading Dose: Give over 2030 min. Continuous: Follow with infusion at 50 mL/h. Use central venous catheter exclusively for aprotinin. INCOMPATIBILITIES Solution/additive: amino acids, corticosteroids, fat emulsion, heparin, tetracyclines. |
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