|ASCORBIC ACID (VITAMIN C)
Apo-C , Ascorbicap, Cebid, Cecon, Cenolate, Cemill, C-Span, Cetane, Cevalin, Cevi-Bid, CeVi-Sol , Cevita, Flavorcee, Redoxon , Schiff Effervescent Vitamin C, Vita-C
Pregnancy Category: C
25 mg, 50 mg, 100 mg, 250 mg, 500 mg, 1000 mg tablets; 250 mg/mL, 500 mg/mL injection
Water-soluble vitamin essential for synthesis and maintenance of collagen and intercellular ground substance of body tissue cells, blood vessels, cartilage, bones, teeth, skin, and tendons. Unlike most mammals, humans are unable to synthesize ascorbic acid in the body; therefore it must be consumed daily.
Increases protection mechanism of the immune system, thus supporting wound healing. Necessary for wound healing and resistance to infection.
Prophylaxis and treatment of scurvy and as a dietary supplement.
To acidify urine; to prevent and treat cancer; to treat idiopathic methemoglobinemia; as adjuvant during deferoxamine therapy for iron toxicity; in megadoses will possibly reduce severity and duration of common cold. Widely used as an antioxidant in formulations of parenteral tetracycline and other drugs.
Use of sodium ascorbate in patients on sodium restriction; use of calcium ascorbate in patients receiving digitalis. Safety during pregnancy (category C) or lactation is not established.
Excessive doses in patients with G6PD deficiency; hemochromatosis, thalassemia, sideroblastic anemia, sickle cell anemia; patients prone to gout or renal calculi.
Adult: PO/IV/IM/SC 150500 mg/d in 12 doses
Child: PO/IV/IM/SC 100300 mg/d in divided doses
Adult: PO/IV/IM/SC 4560 mg/d
Child: PO/IV/IM/SC 3060 mg/d
Adult: PO/IV/IM/SC 412 g/d in divided doses
Child: PO/IV/IM/SC 500 mg q68h
Verify correct IV concentration and rate of infusion for children with physician.
PREPARE: Direct/Continuous/Intermittent: • Give undiluted or diluted in solutions such as NS, D5W, D5/NS, RL.• Be aware that parenteral vitamin C is incompatible with many drugs. • Consult pharmacist for compatibility information.
ADMINISTER: Direct: Give undiluted at a rate of 100 mg or a fraction thereof over 1 min. Continuous/Intermittent: Give at ordered rate determined by volume of solution to be infused.
INCOMPATIBILITIES Solution/additive: Aminophylline, bleomycin, cephapirin, erythromycin, nafcillin, sodium bicarbonate, warfarin. Y-site: Cefazolin, doxapram, sodium bicarbonate.
High doses of ascorbic acid can produce false-negative results for urine glucose with glucose oxidase methods (e.g., Clinitest, TesTape, Diastix); false-positive results with copper reduction methods (e.g., Benedict's solution, Clinitest); and false increases in serum uric acid determinations (by enzymatic methods). Interferes with urinary steroid (17-OHCS) determinations (by modified Reddy, Jenkins, Thorn procedure), decreases in serum bilirubin, and may cause increases in serum cholesterol, creatinine, and uric acid (methodologic inferences). May produce false-negative tests for occult blood in stools if taken within 4872 h of test.
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