Classifications: prostaglandin; abortifacient
Pregnancy Category: D
250 mcg/mL injection
Synthetic analog of naturally occurring prostaglandin F2 alpha with longer duration of biologic activity. Stimulates myometrial contractions of gravid uterus; contractions are qualitatively similar to those occurring at term labor. Mean time to abortion 16 h; mean dose required 2.6 mL. Length of time to abortion and total dose of carboprost required decrease with greater parity but increase with greater gestational age. Can be employed as abortifacient even if membranes are ruptured.
Effectively stimulates uterine contraction and is used to induce abortion over a wide range of gestational age. Useful in treatment of postpartum hemorrhage due to uterine atony unresponsive to usual measures.
To induce abortion between 13th and 20th week of pregnancy, as calculated from first day of last menstrual period. Also for refractory postpartum bleeding.
To reduce blood loss secondary to uterine atony; to induce labor in intrauterine fetal death and hydatidiform mole.
Acute pelvic inflammatory disease; active cardiac, pulmonary, renal, or hepatic disease; pregnancy (category D); lactation.
History of asthma; adrenal disease; anemia; hypotension; hypertension; diabetes mellitus; epilepsy; history of uterine surgery; cervical stenosis; fibroids.
|Abortion, Postpartum Bleeding
Adult: IM Initial: 250 mcg (1 mL) repeated at 1 ½3 ½-h intervals if indicated by uterine response. Dosage may be increased to 500 mcg (2 mL) if uterine contractility is inadequate after several doses of 250 mcg (1 mL), not to exceed total dose of 12 mg or continuous administration for more than 2 d.
Assessment & Drug Effects
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