CASPOFUNGIN (cas-po-fun'gin) Cancidas Classifications: anti-infective; antibiotic; echinocandin antifungal Pregnancy Category: C |
50 mg and 70 mg powder for injection
Caspofungin is an antifungal agent that inhibits the synthesis of an integral component of the fungal cell wall of susceptible Aspergillus species and Candida species.
Interferes with reproduction and growth of susceptible fungi.
Treatment of invasive aspergillosis in those refractory to or intolerant of other antifungal therapies; empirical therapy for presumed fungal infection with febrile neutropenia; treatment of candidemia and intra-abdominal abscesses, peritonitis, and pleural space infections due to Candida. Susceptible organisms include Aspergillus (A. flavus, A. fumigatus, A. terreu) and Candida (C. albicans, C. glabrata, C. krusei, C. lusitaniae, C. parapsilosis, C. tropicalis).
Treatment of esophageal candidiasis with or without oropharyngeal candidiasis (thrush).
Hypersensitivity to any component of this product; pregnancy (category C); not studied in patients with ESRF, or children.
Patients with moderate hepatic insufficiency; concomitant use of cyclosporine; lactation.
Invasive Aspergillosis, Empirical Therapy, Candida
Adult: IV Loading Dose: 70 mg day 1 IV Maintenance Dose: 50 mg qd thereafter |
Intravenous
PREPARE: IV Infusion: Reconstitute a 50 mg or 70 mg vial with 10.5 mL of NS, sterile water for injection, or bacteriostatic water for injection to yield 5 mg/mL and 7 mg/mL, respectively. Mix gently until clear. Withdraw 10 mL of reconstituted solution and add to 250 mL of NS, ½NS, or 0.225% NS, or RL. DO NOT use diluents or IV solutions containing dextrose. ADMINISTER: IV Infusion: Give slowly over at least 1 h. Do not coinfuse with any other medication. INCOMPATIBILITIES Solution/additive: Any dextrose-containing solution. Do not mix or co-infuse with any other medications. |
Assessment & Drug Effects
Patient & Family Education