DIMENHYDRINATE (dye-men-hye'dri-nate) Apo-Dimenhydrinate , Calm-X, Dimenhydrinate Injection, Dimentabs, Dinate, Dommanate, Dramanate, Dramamine, Dramilin, Dramocen, Dramoject, Dymenate, Gravol , Hydrate, Marmine, Motion-Aid, Nauseatol , Novodimenate , PMS Dimenhydrinate , Travamine , Travel Aid, Travel Eze, Wehamine Classifications: antihistamine (h1-receptor antagonist); antiemetic; antivertigo agent Prototype: Diphenhydramine Pregnancy Category: B |
50 mg tablets; 50 mg/mL injection; 15.62 mg/5 mL, 12.5 mg/4 mL, 12.5 mg/5 mL liquid
H1-receptor antagonist and salt of diphenhydramine, with which it shares similar properties.
Precise mode of antinauseant action not known, but thought to involve ability to inhibit cholinergic stimulation in vestibular and associated neural pathways.
Chiefly in prevention and treatment of motion sickness. Also has been used in management of vertigo, nausea, and vomiting associated with radiation sickness, labyrinthitis, Ménière's syndrome, stapedectomy, anesthesia, and various medications.
Narrow-angle glaucoma, prostatic hypertrophy. Safe use during pregnancy (category B), lactation, or in children <2 y is not established.
Convulsive disorders.
Motion Sickness Adult: PO 50100 mg q46h (max: 400 mg/24 h) IV/IM 50 mg as needed Child: PO 26 y, up to 25 mg q68h (max: 75 mg/24 h); 612 y, 2550 mg q68h (max:150 mg/24 h) IV/IM 26 y, 1.25 mg/kg q.i.d. up to 300 mg/d; 612 y, 1.25 mg/kg q.i.d. up to 300 mg/d |
Intravenous PREPARE: Direct: Dilute each 50 mg in 10 mL of NS. ADMINISTER: Direct: Give each 50 mg or fraction thereof over 2 min. INCOMPATIBILITIES Solution/additive: Aminophylline, amobarbital, butorphanol, chlorpromazine, glycopyrrolate, hydroxyzine, midazolam, pentobarbital, prochlorperazine, promazine, promethazine, thiopental. |
Skin testing procedures should not be performed within 72 h after use of an antihistamine.
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