FLUCONAZOLE (flu-con'a-zole) Diflucan Classifications: antiinfective; antibiotic; antifungal Pregnancy Category: C |
50 mg, 100 mg, 150 mg, 200 mg tablets; 10 mg/mL, 40 mg/mL suspension; 2 mg/mL injection
Fungistatic; may also be fungicidal depending on concentration. Interferes with formation of ergosterol, the principal sterol in the fungal cell membrane that, when depleted, interrupts membrane function.
Antifungal properties are related to the drug effect on the fungal cell membrane functioning.
Cryptococcal meningitis and oropharyngeal and systemic candidiasis, both commonly found in AIDS and other immunocompromised patients; vaginal candidiasis.
Hypersensitivity to fluconazole or other azole antifungals; pregnancy (category C), lactation.
AIDS or malignancy; hepatic impairment.
Oropharyngeal Candidiasis Adult: PO/IV 200 mg day 1, then 100 mg q.d. x 2 wk Child: PO/IV 36 mg/kg/d Esophageal Candidiasis Adult: PO/IV 200 mg day 1, then 100 mg q.d. x 3 wk Child: PO/IV 36 mg/kg/d Systemic Candidiasis Adult: PO/IV 400 mg day 1, then 200 mg q.d. x 4 wk Child: PO/IV 36 mg/kg/d Vaginal Candidiasis Adult: PO 150 mg x 1 dose Cryptococcal Meningitis Adult: PO/IV 400 mg day 1, then 200 mg q.d. x 1012 wk Child: PO/IV 36 mg/kg/d |
Intravenous PREPARE: Continuous: Packaged ready for use as a 2 mg/mL solution. Remove wrapper just prior to use. ADMINISTER: Continuous: Give at a maximum rate of approximately 200 mg/h. Give after hemodialysis is completed.
INCOMPATIBILITIES Solution/additive: Trimethoprim-sulfamethoxazole. Y-site: Amphotericin B, amphotericin B cholesteryl, ampicillin, calcium gluconate, ceftazidime, ceftriaxone, cefuroxime, chloramphenicol, clindamycin, diazepam, digoxin, erythromycin, furosemide, haloperidol, hydroxyzine, imipenem-cilastatin, pentamidine, piperacillin, ticarcillin, trimethoprim-sulfamethoxazole. |
Assessment & Drug Effects
Patient & Family Education