Fumide , Furomide , Lasix, Luramide
Classifications: electrolytic and water balance agent; loop diuretic
Pregnancy Category: C
20 mg, 40 mg, 80 mg tablets; 10 mg/mL, 40 mg/5 mL oral solution; 10 mg/mL injection
Rapid-acting potent sulfonamide "loop" diuretic and antihypertensive with pharmacologic effects and uses almost identical to those of ethacrynic acid. Exact mode of action not clearly defined; decreases renal vascular resistance and may increase renal blood flow.
Inhibits reabsorption of sodium and chloride primarily in loop of Henle and also in proximal and distal renal tubules; an antihypertensive that decreases edema and intravascular volume. Reportedly less ototoxic than ethacrynic acid.
Treatment of edema associated with CHF, cirrhosis of liver, and kidney disease, including nephrotic syndrome. May be used for management of hypertension, alone or in combination with other antihypertensive agents, and for treatment of hypercalcemia. Has been used concomitantly with mannitol for treatment of severe cerebral edema, particularly in meningitis.
History of hypersensitivity to furosemide or sulfonamides; increasing oliguria, anuria, fluid and electrolyte depletion states; hepatic coma; pregnancy (category C), lactation.
Infants, older adults; hepatic cirrhosis, nephrotic syndrome; cardiogenic shock associated with acute MI; history of SLE, history of gout; patients receiving digitalis glycosides or potassium-depleting steroids.
Adult: PO 2080 mg in 1 or more divided doses up to 600 mg/d if needed IV/IM 2040 mg in 1 or more divided doses up to 600 mg/d
Child: PO 2 mg/kg, may be increased by 12 mg/kg q68h (max: 6 mg/kg/dose) IV/IM 1 mg/kg, may be increased by 1 mg/kg q2h if needed (max: mg/kg/dose)
Neonate: PO 14 mg/kg q1224h IV/IM 12 mg/kg q1224h
Adult: PO 1040 mg b.i.d. (max: 480 mg/d)
PREPARE: Direct: Give undiluted.
ADMINISTER: Direct: Give undiluted at a rate of 20 mg or a fraction thereof over 1 min. With high doses a rate of 4 mg/min is recommended to decrease risk of ototoxicity.
INCOMPATIBILITIES Solution/additive: Buprenorphine, chlorpromazine, ciprofloxacin, diazepam, diphenhydramine, dobutamine, doxapram, doxorubicin, droperidol, erythromycin, gentamicin, isoproterenol, labetalol, meperidine, metoclopramide, milrinone, netilmicin, pancuronium, prochlorperazine, promethazine, quinidine, thiamine vinblastine, vincristine. Y-site: Amrinone, amsacrine, azithromycin, ciprofloxacin, diazepam, diltiazem, dobutamine, diphenhydramine, dopamine, doxorubicin, droperidol, esmolol, filgrastim, fluconazole, gemcitabine, gentamicin, hydralazine, idarubicin, methocarbamol, metoclopramide, midazolam, milrinone, morphine, netilmicin, nicardipine, ondansetron, quinidine, thiopental, tobramycin, vecuronium, vinblastine, vincristine, vinorelbine, TPN.
Furosemide may cause elevations in BUN, serum amylase, cholesterol, triglycerides, uric acid and blood glucose levels, and may decrease serum calcium, magnesium, potassium, and sodium levels.
Assessment & Drug Effects
Patient & Family Education