|INSULIN, ISOPHANE (NPH)
Humulin N, Insulatard NPH, Mixtard, Novolin 70/30, Novolin N
Classifications: hormone and synthetic substitute; antidiabetic agent; intermediate acting insulin
Pregnancy Category: B
Intermediate-acting, cloudy suspension of zinc insulin crystals modified by protamine in a neutral buffer. NPH Iletin II (pork), and Insulatard NPH are "purified" or "single component" insulins that have been purified and are less likely to cause allergic reactions than nonpurified preparations.
Lowers blood glucose levels by increasing peripheral glucose uptake, especially by skeletal muscle and fat tissue, and by inhibiting the liver from changing glycogen to glucose. Therapeutic effect controls postprandial hyperglycemia, usually without supplemental doses of insulin injection.
Used to control hyperglycemia in the diabetic patient. Mixtard and Novolin 70/30 are fixed combinations of purified regular insulin 30% and NPH 70%.
During episodes of hypoglycemia or in patients sensitive to any ingredient in the formulation.
In insulin resistant patients, hyperthyroidism or hypothyroidism; lactation, older adults, pregnancy (category B), renal or hepatic impairment. Safety and efficacy in children <3 y are not established.
Adult: SC Individualized doses (see INSULIN, REGULAR)
(see INSULIN, REGULAR)
Assessment & Drug Effects
Patient & Family Education