Classifications: gastrointestinal agent; emetic
Pregnancy Category: C
15 mL, 30 mL doses
Derived from dried rhizomes and roots of Cephaelis ipecacuanha. Contains cephaeline (produces emesis) and emetine, a toxic alkaloid that is excreted slowly from the body. Emetine can cause potentially fatal cumulative toxicity with repeated use. It appears to inhibit protein synthesis and energy production in muscle tissue with resultant skeletal and cardiac muscle toxicity.
Acts locally on gastric mucosa and centrally on chemoreceptor trigger zone (CTZ) in the medulla to induce vomiting.
Emergency emetic to remove unabsorbed ingested poisons.
Comatose, semicomatose, inebriated, deeply sedated patients; patients in shock; patients with depressed gag reflex; seizures, active or impending; impaired cardiac function; arteriosclerosis; treatment of ingested strong alkali, acids, or other corrosives, strychnine, petroleum distillates, volatile oils, or rapid-acting CNS depressants.
Safe use in pregnancy (category C), lactation, or infants <6 mo is not established.
Adult: PO 30 mL followed by 12 240 mL (8 oz) glasses of water, may repeat once in 20 min if necessary
Child: PO >1 y, 15 mL followed by 12 240 mL (8 oz) glasses of water, may repeat once in 20 min if necessary; <1 y, 510 mL followed by 120240 mL (48 oz) of water, may repeat once in 20 min if necessary
Assessment & Drug Effects
Patient & Family Education