LATANOPROST 
(la-tan'o-prost)
Xalatan
Classifications: eye preparation; prostaglandin
Pregnancy Category: C
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0.005% solution
Prostaglandin analog that is thought to reduce intraocular pressure (IOP) by increasing the outflow of aqueous humor.
Reduces elevated intraocular pressure in patients with open-angle glaucoma.
Treatment of open-angle glaucoma, ocular hypertension and elevated intraocular pressure (IOP).
Hypersensitivity to latanoprost or another component in the solution; pregnancy (category C); intraocular infection; conjunctivitis.
Lactation; active intraocular inflammation such as: iritis or uveitis; patients at risk for macular edema; hepatic or renal
impairment. Safety and effectiveness in children are not established.
Glaucoma
Adult: Ophthalmic 1 drop in affected eye(s) q.d. in evening
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Installation
- Ensure that contact lenses are removed prior to installation and not reinserted for 15 min after installation.
- Apply only to affected eye(s). Ensure that only one drop is instilled.
- Do not allow tip of dropper to touch eye.
- Wait at least 5 min before/after instillation of other eye drops.
- Refrigerate at 2°–8° C (36°–46° F). Protect from light.
Body as a Whole: Headaches, asthenia, flu-like symptoms. GI: Abnormal liver function tests. Skin: Rash. Special Senses: Conjunctival hyperemia, growth of eyelashes, ocular pruritus, ocular dryness, visual disturbance, ocular burning, foreign body sensation, eye pain, pigmentation of the periocular skin,
blepharitis, cataract, superficial punctate keratitis, eyelid erythema, ocular irritation, and eyelash darkening, eye discharge,
tearing, photophobia, allergic conjunctivitis, increases in iris pigmentation (brown pigment), conjunctival edema.
Drug: Precipitation may occur if mixed with eye drops containing thimerosal; space other eye preparations at least 5 min apart.
Absorption: Absorbed through the cornea. Onset: 3–4 h. Peak IOP reduction: 8–12 h. Distribution: Minimal systemic distribution. Metabolism: Hydrolyzed in aqueous humor to active form. Elimination: Renally excreted. Half-Life: 17 min.
Assessment & Drug Effects
- Withhold eye drops and notify physician if acute intraocular inflammation (iritis or uveitis) or external eye inflammation
are noted.
- Note that increased pigmentation of the iris and eyelid, and additional growth of eyelashes on the treated eye are adverse
effects that may develop gradually over months to years.
Patient & Family Education
- Contact physician immediately if any ocular reaction occurs, especially conjunctivitis and lid reactions.
- Note: Increased pigmentation of the iris and eyelid, and additional growth of eyelashes on the treated eye, are possible adverse
effects of this drug. Persons with light colored eyes receiving treatment to one eye may develop a darker eye.
- Do not breast feed while using this drug.
1%)
Canadian drug name;