Depoject, Depo-Medrol, Depopred, Duralone, M-Prednisol, Rep-Pred
METHYLPREDNISOLONE SODIUM SUCCINATE
Classifications: hormones and synthetic substitutes; adrenal corticosteroid; glucocorticoid; antiinflammatory
Pregnancy Category: C
Methylprednisolone 2 mg, 4 mg, 8 mg, 16 mg, 24 mg, 32 mg tablets
Methylprednisolone Acetate 20 mg/mL, 40 mg/mL, 80 mg/mL injection
Methylprednisolone Sodium Succinate 40 mg, 125 mg, 500 mg, 1 g, 2 g powder for injection
Intermediate-acting synthetic adrenal corticosteroid with similar glucocorticoid activity; has considerably fewer sodium and water retention effects than hydrocortisone. Acetate has longer duration of action and more rapid onset of activity than parent compound. Sodium succinate form is characterized by rapid onset of action and is used for emergency therapy of short duration. It inhibits phagocytosis, and release of allergic substances. Also modifies the immune response of the body to various stimuli.
Antiinflammatory and immunosuppressive properties.
An antiinflammatory agent in the management of acute and chronic inflammatory diseases, for palliative management of neoplastic diseases, and for control of severe acute and chronic allergic processes. High-dose, short-term therapy: management of acute bronchial asthma, prevention of fat embolism in patient with long-bone fracture.
Acetate form used as a long-acting contraceptive and for spinal cord injury, lupus nephritis, multiple sclerosis.
Systemic fungal infections. Safety during pregnancy (category C) or lactation is not established.
Cushing's syndrome; GI ulceration; hypertension; varicella, vaccinia; diabetes mellitus; emotional instability or psychotic tendencies.
Adult: PO 260 mg/d in 1 or more divided doses IM (Acetate) 480 mg/wk for 14 wk; (Succinate) 10250 mg q6h IV 10250 mg q6h
Child: PO/IM/IV 0.51.7 mg/kg/d divided q612h
Acute Spinal Cord Injury
Adult/Child: IV 30 mg/kg over 15 min, followed in 45 min by 5.4 mg/kg/h times 23 h; dose should be tapered down after long-term therapy
PREPARE: Direct/Intermittent: Available in ACT-O-Vial from which the desired dose may be withdrawn after initial dilution with supplied diluent. May be further diluted according to physician's orders.
ADMINISTER: Direct/Intermittent: Give each 500 mg or fraction thereof over 23 min.
INCOMPATIBILITIES Solution/additive: Dextrose 5%/sodium chloride 0.45%, calcium gluconate, glycopyrrolate, metaraminol, nafcillin, penicillin G sodium, doxapram. Y-site: Allopurinol, amsacrine, ciprofloxacin, cisatracurium (2 mg/mL concentration), diltiazem, etoposide, filgrastim, gemcitabine, ondansetron, paclitaxel, potassium chloride, propofol, sargramostim, vinorelbine.
Assessment & Drug Effects
Patient & Family Education