OCTREOTIDE ACETATE (oc-tre'o-tide) Sandostatin, Sandostatin LAR depot Classifications: hormones and synthetic substitutes; antidiarrheal Pregnancy Category: B |
0.05 mg/mL, 0.1 mg/mL, 0.2 mg/mL, 0.5 mg/mL, 1 mg/mL injection; 10 mg/5 mL, 20 mg/5 mL, 30 mg/5 mL depot injection
A long-acting peptide that mimics the natural hormone somatostatin. Suppresses secretion of serotonin, pancreatic peptides, gastrin, vasoactive intestinal peptide, insulin, glucagon, secretin, and motilin.
Stimulates fluid and electrolyte absorption from the GI tract, prolongs intestinal transit time, and also inhibits the growth hormone.
Symptomatic treatment of severe diarrhea and flushing episodes associated with metastatic carcinoid tumors. Also watery diarrhea associated with vasoactive intestinal peptide (VIP) tumors.
Acromegaly associated with pituitary tumors, fistula drainage, variceal bleeding.
Hypersensitivity to octreotide.
Cholelithiasis, renal impairment; pregnancy (category B); diabetes, and hypothyroidism. It is not known whether drug is excreted in breast milk.
Carcinoid Syndrome Adult: SC 100600 mcg/d in 24 divided doses, titrate to response IM May switch to depot injection after 2 wk at 20 mg q4wk times 2 mo Child: SC 110 mcg/kg/d in 24 divided doses, titrate to response VIPoma Adult: SC 200300 mcg/d in 24 divided doses, titrate to response IM May switch to depot injection after 2 wk at 20 mg q4wk times 2 mo Child: SC 110 mcg/kg/d in 24 divided doses, titrate to response Acromegaly Adult: SC 50 mcg t.i.d., titrate up to 100 mcg500 mcg t.i.d. IM May switch to depot injection after 2 wk at 20 mg q4wk times at least 3 mo, then reassess |
Intravenous PREPARE: Direct: Give undiluted. Intermittent: Dilute in 50200 mL D5W. ADMINISTER: Direct: Give a single dose over 3 min. In carcinoid give rapid IV bolus over 60 sec. Intermittent: Give over 1530 min. |
Assessment & Drug Effects
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