Classifications: antiinfective; anthelmintic
Pregnancy Category: C
250 mg capsules
Hydroquinone derivative prepared in the presence of Aspergillus sclerotium. Mechanism of action not fully explained, but it appears that drug-induced strong contractions and paralysis of worm musculature
leads to immobilization of their suckers and dislodgment from their usual residence in mesenteric veins to the liver.
Dislodgment of schistosomes begins about 2 d after single oral dose; movement is not complete until 6 d after treatment with
the drug. After treatment, surviving unpaired females return to mesenteric vessels; however, oviposition (egg laying) seems
to stop in 2448 h after drug treatment, reducing egg load and removing principal cause of pathology associated with
All stages of Schistosoma mansoni infection, including acute and chronic phases with hepatosplenic involvement.
Safe use during pregnancy (category C), lactation, or in children is not established.
History of convulsant disorders.
Adult: PO 1215 mg/kg as single dose
Child: PO <30 kg, 10 mg/kg times 2 doses at 28 h intervals
CNS: Transitory dizziness, drowsiness, headache; persistent fever (in patients being treated in Egypt); EEG abnormalities, convulsions (rare). GI: Anorexia, nausea, vomiting, abdominal pain, elevated liver enzyme concentrations. Hematologic: Increased erythrocyte sedimentation rate, reticulocyte count, and increased or decreased leukocyte count. Skin: Urticaria. Urogenital: Red-orange urine.
Food: Rate and extent of absorption are decreased by food.
Absorption: Readily absorbed from GI tract. Peak: 13 h. Metabolism: Extensively metabolized in GI mucosa. Elimination: Excreted in urine. Half-Life: 12.5 h.
- Give on an empty stomach, if possible.
- Administer with food if necessary to reduce GI distress and improve tolerance.
- Store product in tightly closed container at controlled room temperature less than 30° C (86° F).
Assessment & Drug Effects
- Supervise ambulation and use other safety precautions because >30% of patients experience dizziness or drowsiness.
- If patient has a history of seizures, the possibility of seizures is increased because of drug action (occurs within hours
of drug administration).
Patient & Family Education
- Use caution while driving or performing other tasks requiring alertness because drug can cause dizziness or drowsiness.
- Be aware that drug may change the normal urine color to a harmless orange-red.
- Do not breast feed while taking this drug without consulting physician.