Ox-Pam , Serax, Zapex
Classifications: central nervous system agent; anxiolytic; sedative-hypnotic; benzodiazepine
Pregnancy Category: C
Controlled Substance: Schedule IV
10 mg, 15 mg, 30 mg capsules; 15 mg tablets
Benzodiazepine derivative related to lorazepam. Effects are mediated by the inhibitory neurotransmitter GABA. Acts on the
thalamic, hypothalamic, and limbic levels of CNS.
Has anxiolytic, sedative, hypnotic, and skeletal muscle relaxant effects.
Management of anxiety and tension associated with a wide range of emotional disturbances. Also to control acute withdrawal
symptoms in chronic alcoholism.
Hypersensitivity to oxazepam and other benzodiazepines; psychoses, pregnancy (category C), lactation, children <12 y; acute-angle
glaucoma, acute alcohol intoxication.
Older adult and debilitated patients; impaired kidney and liver function; addiction-prone patients; COPD; mental depression.
Adult: PO 1030 mg t.i.d. or q.i.d.
Acute Alcohol Withdrawal
Adult: PO 1530 mg t.i.d. or q.i.d.
CNS: Drowsiness, dizziness, mental confusion, vertigo, ataxia, headache, lethargy, syncope, tremor, slurred speech, paradoxic reaction (euphoria,
excitement). GI: Nausea, xerostomia, jaundice. Skin: Skin rash, edema. CV: Hypotension, edema. Hematologic: Leukopenia. Urogenital: Altered libido.
Drug: Alcohol, cns depressants, anticonvulsants potentiate CNS depression; cimetidine increases oxazepam plasma levels, increasing its toxicity; may decrease antiparkinsonism effects of levodopa; may increase phenytoin levels; smoking decreases sedative and antianxiety effects. Herbal: Kava-kava, valerian may potentiate sedation.
Absorption: Readily absorbed from GI tract. Peak: 23 h. Distribution: Crosses placenta; distributed into breast milk. Metabolism: Metabolized in liver. Elimination: Primarily excreted in urine, some in feces. Half-Life: 28 h.
- Give with food if GI upset occurs.
- Store in tightly closed container at 15°30° C (59°86° F) unless otherwise specified.
Assessment & Drug Effects
- Observe older adult patients closely for signs of overdosage. Report to physician if daytime psychomotor function is depressed.
- Lab tests: Perform liver function and white blood cell counts on a regular planned basis.
- Note: Excessive and prolonged use may cause physical dependence.
Patient & Family Education
- Report promptly any mild paradoxic stimulation of affect and excitement with sleep disturbances that may occur within the
first 2 wk of therapy. Dosage reduction is indicated.
- Do not change dose or dose schedule and refrain from using drug to treat a self-diagnosed condition.
- Consult physician before self-medicating with OTC drugs.
- Do not drive or engage in potentially hazardous activities until response to drug is known.
- Do not drink alcoholic beverages while taking oxazepam. The CNS depressant effects of each agent may be intensified.
- Contact physician if you intend to or do become pregnant during therapy about discontinuing the drug.
- Withdraw drug slowly following prolonged therapy to avoid precipitating withdrawal symptoms (seizures, mental confusion, nausea,
vomiting, muscle and abdominal cramps, tremulousness, sleep disturbances, unusual irritability, hyperhidrosis).
- Do not breast feed while taking this drug.