OXYMETAZOLINE HYDROCHLORIDE (ox-i-met-az'oh-leen) Afrin, Dristan Long Lasting, Duramist Plus, Duration, Nafrine , Neo-Synephrine 12 Hour, Nostrilla, Sinex Long Lasting Classifications: eye, ear, nose, and throat (eent) preparation; vasoconstrictor, decongestant; sympathomimetic Prototype: Naphazoline Pregnancy Category: C |
0.025%, 0.05% solution
Sympathomimetic agent that acts directly on alpha receptors of sympathetic nervous system. No effect on beta receptors.
Constricts smaller arterioles in nasal passages and has prolonged decongestant effect.
Relief of nasal congestion in a variety of allergic and infectious disorders of the upper respiratory tract; used as nasal tampon to facilitate intranasal examination or before nasal surgery. Also used as adjunct in treatment and prevention of middle ear infection by decreasing congestion of eustachian ostia.
Use in children <2 y. Safe use during pregnancy (category C) or lactation is not established.
Within 14 d of MAO inhibitors, coronary artery disease, hypertension, hyperthyroidism, diabetes mellitus.
Nasal Congestion Adult: Intranasal 23 drops or 23 sprays of 0.05% solution into each nostril b.i.d. for up to 35 d Child: Intranasal 25 y, 23 drops or 23 sprays of 0.025% solution into each nostril b.i.d. for up to 35 d; >6 y, same as for adult |
Assessment & Drug Effects
Patient & Family Education