Nembutal Sodium, Novopentobarb
Classifications: central nervous system agent; anxiolytic; sedative-hypnotic; barbiturate
Pregnancy Category: D
Controlled Substance: Schedule II
50 mg, 100 mg capsules; 20 mg/5 mL liquid; 30 mg, 60 mg, 120 mg, 200 mg suppositories; 50 mg/mL injection
Short-acting barbiturate. Potent respiratory depressant. Initially, barbiturates suppress REM sleep, but with chronic therapy REM sleep returns to normal. Has no analgesic properties, and small doses may increase reaction to painful stimuli.
Effective as a sedative and hypnotic. CNS depression may range from mild sedation to coma, depending on dosage, route of administration, degree of nervous system excitability, and drug tolerance.
Sedative or hypnotic for preanesthetic medication, induction of general anesthesia, adjunct in manipulative or diagnostic procedures, and emergency control of acute convulsions.
Pregnancy (category D) or lactation. History of sensitivity to barbiturates; parturition, fetal immaturity, uncontrolled pain. Use of sterile injection containing polyethylene glycol vehicle in patients with renal insufficiency.
Pregnant women with toxemia or history of bleeding.
Adult: PO 2030 mg b.i.d. to q.i.d.
Child: PO 26 mg/kg/d in 3 divided doses (max: 100 mg/d)
Adult: PO 150200 mg in 2 divided doses IM 150200 mg in 2 divided doses IV 100 mg; may increase to 500 mg if necessary
Adult: PO 120200 mg. IM 150200 mg
Child: PO 30120 mg. IM 26 mg/kg (max: 100 mg)
Note: Do not give within 14 d of starting/stopping a MAO inhibitor.Intramuscular
PREPARE: Direct: Give undiluted or diluted (preferred) with sterile water, D5W, NS, or other compatible IV solutions.
ADMINISTER: Direct: Give slowly. Do not exceed rate of 50 mg/min.
INCOMPATIBILITIES Solution/additive: Chlorpheniramine, codeine, ephedrine, hydrocortisone, hydroxyzine, inulin, levorphanol, methadone, norepinephrine, tetracyclines, penicillin G, pentazocine, phenytoin, promazine, promethazine, sodium bicarbonate, streptomycin, succinylcholine, triflubromazine, vancomycin, cimetidine, benzquinamide, butorphanol, chlorpromazine, dimenhydrinate, diphenhydramine, droperidol, fentanyl, glycopyrrolate, meperidine, midazolam, morphine, nalbuphine, perphenazine, prochlorperazine, ranitidine. Y-site: Cimetidine, butorphanol, glycopyrrolate, midazolam, nalbuphine, perphenazine, ranitidine.
Assessment & Drug Effects
Patient & Family Education