Classifications: autonomic nervous system agent; alpha-adrenergic antagonist (blocking agent), sympatholytic
Pregnancy Category: C
5 mg injection
Alpha-adrenergic blocking agent structurally related to tolazoline but with more potent blocking effects. Competitively blocks alpha-adrenergic receptors, but action is transient and incomplete. Prevents hypertension resulting from elevated levels of circulating epinephrine or norepinephrine.
Causes vasodilation and decreases general vascular resistance and pulmonary arterial pressure, primarily by direct action on vascular smooth muscle. Through stimulation of beta-adrenergic receptors, produces positive inotropic and chronotropic cardiac effects and increases cardiac output.
Diagnosis of pheochromocytoma and to prevent or control hypertensive episodes prior to or during pheochromocytomectomy.
Prevention of dermal necrosis and sloughing following IV administration or extravasation of norepinephrine.
MI (previous or present), coronary artery disease. Safety during pregnancy (category C) or lactation is not established.
Gastritis, peptic ulcer.
|To Prevent Hypertensive Episode during Surgery
Adult: IV/IM 25 mg as needed
Child: IV/IM 1 mg or 0.1 mg/kg (max: 5 mg/dose)
To Test for Pheochromocytoma
Adult: IV/IM 5 mg
Child: IV/IM 0.1 mg/kg
To Prevent Necrosis from Norepinephrine Infusions
Adult: IV 10 mg added to each liter of IV fluid containing norepinephrine
To Treat Catecholamine Extravasation
Adult/Child: Intradermal 510 mg diluted in 10 mL of normal saline injected into affected area within 12 h of extravasation
Neonate: Intradermal 2.55 mg diluted in 10 mL of normal saline injected into affected area within 12 h of extravasation (max: dose 0.1 mg/kg or 2.5 mg total)
Note: Place patient in supine position when receiving drug parenterally. Monitor BP and pulse q2min until stabilized.Intramuscular
PREPARE: Direct: Reconstitute as for IM. May be further diluted with up to 10 mL of sterile water. Use immediately.
ADMINISTER: Direct: Give a single dose over 60 sec.
Assessment & Drug Effects
Patient & Family Education