Econopred, Key-Pred, Pred Forte, Predcor
PREDNISOLONE SODIUM PHOSPHATE
AK-Pred, Hydeltrasol, Inflamase, Inflamase Forte, Inflamase Mild, Pred Mild
Hydeltra-T.B.A., Prednisol TBA
Classifications: hormones and synthetic substitutes; adrenal corticosteroid; glucocorticoid
Pregnancy Category: C
Prednisolone 5 mg tablet; 5 mg/5 mL, 15 mg/5 mL syrup, 0.12%, 0.125%, 1% ophthalmic suspension
Acetate 25 mg/mL, 50 mg/mL injection
Sodium Phosphate 5 mg/5 mL liquid; 20 mg/mL injection; 0.125%, 1% ophthalmic solution
Tebuate 20 mg/mL injection
Analog of hydrocortisone with 35 times greater potency. Mineralocorticoid properties are minimal, and potential for
sodium and water retention as well as potassium loss is reduced.
Effective as an anti-inflammatory agent.
Principally as an antiinflammatory and immunosuppressant agent.
Safety during pregnancy (category C) or lactation is not established.
Adult: PO 560 mg/d in single or divided doses IM Acetate/Phosphate: 660 mg/d; Tebutate: 260 mg qwk IV Phosphate: 460 mg/d Ophthalmic See Appendix A-1
Child: PO 0.142 mg/kg/d in single or divided doses IM Acetate/Phosphate: 0.040.25 mg/kg 12 times/d IV Phosphate: 0.040.25 mg/kg 12 times/d
Alternate-Day Therapy (ADT) for Patient on Long-Term Therapy
- Give with meals to reduce gastric irritation. If distress continues, consult physician about possible adjunctive antacid therapy.
- With ADT, the 48-h requirement for steroids is administered as a single dose every other morning.
- Be aware that ADT minimizes adverse effects associated with long-term treatment while maintaining the desired therapeutic
- See prednisone for numerous additional nursing implications.
Note: Verify that drug supplied is appropriate for the ordered route. Prednisolone acetate is for IM use.
- Give deep IM into a large muscle.
Endocrine: Hirsutism (occasional), adverse effects on growth and development of the individual and on sperm. Special Senses: Perforation of cornea (with topical drug). Body as a Whole: Sensitivity to heat; fat embolism, hypotension and shock-like reactions. CNS: Insomnia. GI: Gastric irritation or ulceration. Skin: Ecchymotic skin lesions; vasomotor symptoms. Also see prednisone.
rifampin increase steroid metabolism, therefore may need increased doses of prednisolone; amphotericin B,
diuretics add to potassium loss; ambenonium,
pyridostigmine may cause severe muscle weakness in patients with myasthenia gravis; vaccines, toxoids may inhibit antibody response.
Absorption: Readily absorbed from GI tract. Peak: 12 h. Duration: 11.5 d. Distribution: Crosses placenta; distributed into breast milk. Metabolism: Metabolized in liver. Elimination: HPA suppression: 2436 h; Excreted in urine. Half-Life: 3.5 h.
PREPARE: Direct: May be given undiluted. IV Infusion: May be added to 501000 mL of D5W or NS.
ADMINISTER: Direct: Give at a rate of 10 mg or fraction thereof over 60 s. IV Infusion: Do not exceed 10 mg/min.
Assessment & Drug Effects
- Be alert to subclinical signs of lack of improvement such as continued drainage, low-grade fever, and interrupted healing.
In diseases caused by microorganisms, infection may be masked, activated, or enhanced by corticosteroids. Observe and report
exacerbation of symptoms after short period of therapeutic response.
- Be aware that temporary local discomfort may follow injection of prednisolone into bursa or joint.
Patient & Family Education
- Adhere to established dosage regimen (i.e., do not increase, decrease, or omit doses or change dose intervals).
- Report gastric distress or any sign of peptic ulcer.
- Do not breast feed while taking this drug without consulting physician.