PROCHLORPERAZINE (proe-klor-per'a-zeen) Compazine PROCHLORPERAZINE EDISYLATE Compazine PROCHLORPERAZINE MALEATE Compazine, Stemetil Classifications: psychotherapeutic; antipsychotic phenothiazine; gastrointestinal agent; antiemetic Pregnancy Category: C |
5 mg, 10 mg, 25 mg tablets; 10 mg, 15 mg, 30 mg sustained release capsule; 2.5 mg, 5 mg, 25 mg suppositories; 5 mg/mL injection
Edisylate 5 mg/5 mL syrup, 5 mg/mL injection
Phenothiazine derivative similar to chlorpromazine. Mechanism that produces strong antipsychotic effects is unclear, but thought to be related to blockade of postsynaptic dopamine receptors in the brain. Action on the hypothalamus and reticular formation results in sedative effects. Antiemetic effect is produced by suppression of the chemoreceptor trigger zone (CTZ).
Inhibits dopamine reuptake; may be basis for moderate extrapyramidal symptoms. Greater extrapyramidal effects and antiemetic potency but fewer sedative, hypotensive, and anticholinergic effects than chlorpromazine.
Management of manifestations of psychotic disorders, of excessive anxiety, tension, and agitation, and to control severe nausea and vomiting.
Hypersensitivity to phenothiazines; bone marrow depression; comatose or severely depressed states; children <9 kg (20 lb) or 2 y of age; pediatric surgery; short-term vomiting in children or vomiting of unknown etiology; Reye's syndrome or other encephalopathies; history of dyskinetic reactions or epilepsy; pregnancy (category C), lactation.
Patient with previously diagnosed breast cancer, children with acute illness or dehydration.
Severe Nausea, Vomiting, Anxiety, Psychotic Disorders Adult: PO 510 mg t.i.d. or q.i.d.; sustained release: 1015 mg q12h IM 510 mg q34h up to 40 mg/d IV 2.510 mg q68h (max: 40 mg/d) PR 25 mg b.i.d. Child: PO 2.5 mg 13 times/d or 5 mg b.i.d. (max: 15 mg/d) IM 0.13 mg/kg q34h PR 2.5 mg b.i.d. or t.i.d. up to 2025 mg/d |
Intravenous PREPARE: Direct: Dilute each 5 mg (1 mL) in 4 mL of NS or other compatible solution to yield 1 mg/mL. IV Infusion: Dilute in 50100 mL of D5W, NS, D5/0.45% NaCl, RL or other compatible solution. ADMINISTER: Direct: Do not exceed 10 mg for a single dose. Do not give a bolus dose. Give at a maximum rate of 5 mg/min. IV Infusion: Give over 1530 min. Do not exceed direct IV rate. INCOMPATIBILITIES Solution/additive: Aminophylline, amphotericin B, ampicillin, calcium gluceptate, calcium gluconate, cephalothin, chloramphenicol, chlorothiazide, dimenhydrinate, furosemide, hydrocortisone, ketorolac, methohexital, midazolam, morphine, penicillin G sodium, pentobarbital, phenobarbital, sodium bicarbonate, dimenhydrinate, hydromorphone, thiopental. Y-site: Aldesleukin, allopurinol, amifostine, amphotericin B cholesteryl complex, aztreonam, cefepime, etoposide, fludarabine, foscarnet, filgrastim, piperacillin-tazobactam.
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Assessment & Drug Effects
Patient & Family Education