SODIUM BICARBONATE NA(HCO3) (sod'i-um bi-car'bon-ate) Sodium Bicarbonate Classifications: gastrointestinal agent; antacid; fluid and electrolyte balance agent Pregnancy Category: C |
325 mg, 520 mg, 650 mg tablets; 4.2%, 5%, 7.5%, 8.4% injection
Short-acting, potent systemic antacid. Rapidly neutralizes gastric acid to form sodium chloride, carbon dioxide, and water. After absorption of sodium bicarbonate, plasma alkali reserve is increased and excess sodium and bicarbonate ions are excreted in urine, thus rendering urine less acid. Not suitable for treatment of peptic ulcer because it is short-acting, high in sodium, and may cause gastric distention, systemic alkalosis, and possibly acid-rebound.
Short-acting, potent systemic antacid; rapidly neutralizes gastric acid or systemic acidosis.
Systemic alkalinizer to correct metabolic acidosis (as occurs in diabetes mellitus, shock, cardiac arrest, or vascular collapse), to minimize uric acid crystallization associated with uricosuric agents, to increase the solubility of sulfonamides, and to enhance renal excretion of barbiturate and salicylate overdosage. Commonly used as home remedy for relief of occasional heartburn, indigestion, or sour stomach. Used topically as paste, bath, or soak to relieve itching and minor skin irritations such as sunburn, insect bites, prickly heat, poison ivy, sumac, or oak. Sterile solutions are used to buffer acidic parenteral solutions to prevent acidosis. Also as a buffering agent in many commercial products (e.g., mouthwashes, douches, enemas, ophthalmic solutions).
Prolonged therapy with sodium bicarbonate; patients losing chloride (as from vomiting, GI suction, diuresis); heart disease, hypertension; renal insufficiency; peptic ulcer; pregnancy (category C).
Edema, sodium-retaining disorders; lactation; older adult patients.
Antacid Adult: PO 0.32 g 14 times/d or ½ tsp of powder in glass of water Urinary Alkalinizer Adult: PO 4 g initially, then 12 g q4h Child: PO 84840 mg/kg/d in divided doses Cardiac Arrest Adult: IV 1 mEq/kg of a 7.5% or 8.4% solution initially, then 0.5 mEq/kg q10 min depending on arterial blood gas determinations (8.4% solutions contain 50 mEq/50 mL), give over 12 min Child: IV 0.51 mEq/kg of a 4.2% solution q10 min depending on arterial blood gas determinations, give over 12 min Metabolic Acidosis Adult: IV 25 mEq/kg by IV infusion over 48 h Infant: IV 23 mEq/kg/d of a 4.2% solution over 48 h |
Intravenous PREPARE: IV Infusion: May give 4.2% (0.5 mEq/mL) and 5% (0.595 mEq/mL) NaHCO3 solutions undiluted. Dilute 7.5% (0.892 mEq/mL) and 8.4% (1 mEq/mL) solutions with compatible IV solutions. Dilute to at least 4.2% for infants and children. ADMINISTER: IV Infusion: Give a bolus dose only in emergency situations. Usually, the rate is 25 mEq/kg over 48 h; do not exceed 50 mEq/h. Stop infusion immediately if extravasation occurs. Severe tissue damage has followed tissue infiltration. INCOMPATIBILITIES Solution/additive: Alcohol 5%, lactated Ringer's, amoxicillin, ascorbic acid, bupivacaine, carboplatin, carmustine, cisplatin, codeine, corticotropin, dobutamine, dopamine, epinephrine, etidocaine, glycopyrrolate, hydromorphone, imipenem-cilastatin, insulin, isoproterenol, labetalol, levorphanol, lidocaine, magnesium sulfate, meperidine, mepivacaine, meropenem, methadone, metoclopramide, morphine, norepinephrine, oxytetracycline, pentazocine, pentobarbital, phenobarbital, procaine, secobarbital, streptomycin, succinylcholine, tetracycline, thiopental, vancomycin, vitamin B complex with C. Y-site: Allopurinol, amiodarone, amphotericin B cholesteryl complex, calcium chloride, diltiazem, doxorubicin liposome, idarubicin, imipenem/cilastatin, inamrinone, leucovorin, midazolam, nalbuphine, ondansetron, oxacillin, sargramostim, verapamil, vincristine, vindesine, vinorelbine. |
Small increase in blood lactate levels (following IV infusion of sodium bicarbonate); false-positive urinary protein determinations (using ames reagent, sulfacetic acid, heat and acetic acid or nitric acid ring method); elevated urinary urobilinogen levels (urobilinogen excretion increases in alkaline urine).
Assessment & Drug Effects
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