AK-Sulf, Bleph 10, Cetamide, Isopto Cetamide, Ophthacet, Sebizon, Sodium Sulamyd, Sulf-10
Classifications: antiinfective; sulfonamide antibiotic
Pregnancy Category: C
Sulfacetamide10% lotion; 1%, 10%, 15%, 30% solution; 10% ointment
Sulfacetamide/Sulfur10%/5% gel, lotion
Highly soluble sulfonamide that exerts bacteriostatic effect by interfering with bacterial utilization of PABA, thereby inhibiting
folic acid biosynthesis required for bacterial growth.
Effective against a wide range of gram-positive and gram-negative microorganisms.
Ophthalmic preparations are used for conjunctivitis, corneal ulcers, and other superficial ocular infections and as adjunct
to systemic sulfonamide therapy for trachoma. The topical lotion is used for scaly dermatoses, seborrheic dermatitis, seborrhea
sicca, and other bacterial skin infections.
Hypersensitivity to sulfonamides or to any ingredients in the formulation. Pregnancy (category C).
Application of lotion to denuded or debrided skin; lactation.
Adult: Ophthalmic 13 drops of 10%, 15%, or 30% solution into lower conjunctival sac q23h, may increase interval as patient
responds or use 1.52.5 cm (½1 in) of 10% ointment q6h and at h.s.
Adult: Topical Apply thin film to affected area 13 times per day
Temporary stinging or burning sensation, retardation of corneal healing associated with long-term use of ophthalmic ointment. Body as a Whole: Hypersensitivity reactions (Stevens-Johnson syndrome, lupus-like syndrome), superinfections with nonsusceptible organisms.
Tetracaine and other local anesthetics derived from paba may antagonize the antibacterial effects of sulfonamides; silver preparations may precipitate sulfacetamide from solution.
Absorption: Minimal systemic absorption, but may be enough to cause sensitization. Metabolism: Metabolized in liver to inactive metabolites. Elimination: Excreted in urine.
- Be aware that ophthalmic preparations and skin lotion are not interchangeable.
- Check strength of medication prescribed.
- See patient instructions for instilling eye drops.
- Discard darkened solutions; results when left standing for a long time.
- Store at 8°15° C (46°59° F) in tightly closed containers unless otherwise directed.
Assessment & Drug Effects
- Discontinue if symptoms of hypersensitivity appear (erythema, skin rash, pruritus, urticaria).
Patient & Family Education
- Wash hands thoroughly with soap and running water (before and after instillation).
- Examine eye medication; discard if cloudy or dark in color.
- Avoid contaminating any part of eye dropper that is inserted in bottle.
- Tilt head back, pull down lower lid. At the same time, look up while drop is being instilled into conjunctival sac. Immediately
apply gentle pressure just below the eyelid and next to nose for 1 min. Close eyes gently, so as not to squeeze out medication.
- Report purulent eye discharge to physician. Sulfacetamide sodium is inactivated by purulent exudates.