Classifications: antiinfective; antiviral
Pregnancy Category: B
500 mg tablets
An antiviral agent hydrolyzed in the intestinal wall or liver to acyclovir; interferes with viral DNA synthesis. Because of increased GI absorption, the plasma level of this drug is substantially higher than that of acyclovir when both are taken orally.
Active against herpes simplex virus types 1 (HSV-1) and 2 (HSV-2), varicella zoster virus, and cytomegalovirus. Inhibits viral replication.
Herpes zoster (shingles) in immunocompetent adults. Treatment and suppression of recurrent genital herpes; suppression of recurrent herpes in HIV-positive patients; treatment of cold sores.
Hypersensitivity to or intolerance of valacyclovir or acyclovir; pregnancy (category B).
Renal impairment, patients receiving nephrotoxic drugs, advanced HIV disease, allogeneic bone marrow transplant and renal transplant recipients, treatment of disseminated herpes zoster, immunocompromised patients, lactation. Safety and efficacy in children are not established.
Adult: PO 1 g (2 x 500 mg) t.i.d. for 7 d, start within 48 h of onset of zoster rash
Clcr 3049 mL/min: 1 g q12h 1029 mL/min: 1 g q24h <10 mL/min: 500 mg q24h
Treatment of Recurrent Genital Herpes
Adult: PO 500 mg b.i.d. x 3 d
Clcr 29 mL/min: 500 mg q.d.
Suppression of Recurrent Genital Herpes
Adult: PO 1 g q.d.
Treatment of Cold Sores
Adult: PO 2 g 12 h x 2 doses
Assessment & Drug Effects
Patient & Family Education